Optimizing β-Lactams against Tuberculosis
نویسندگان
چکیده
منابع مشابه
In Vitro Activity of β-Lactams in Combination with β-Lactamase Inhibitors against Multidrug-Resistant Mycobacterium tuberculosis Isolates.
The combination of β-lactams and β-lactamase inhibitors has been shown to have potent in vitro activity against multidrug-resistant tuberculosis (MDR-TB) isolates. In order to identify the most potent β-lactam-β-lactamase inhibitor combination against MDR-TB, we selected nine β-lactams and three β-lactamase inhibitors, which belong to different subgroups. A total of 121 MDR-TB strains were incl...
متن کاملIn vitro and in vivo efficacy of β-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis.
Beta-lactams, in combination with beta-lactamase inhibitors, are reported to have activity against Mycobacterium tuberculosis bacteria growing in broth, as well as inside the human macrophage. We tested representative beta-lactams belonging to 3 different classes for activity against replicating M. tuberculosis in broth and nonreplicating M. tuberculosis under hypoxia, as well as against strept...
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UNLABELLED Most β-lactam antibiotics are ineffective against Mycobacterium tuberculosis due to the microbe's innate resistance. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has prompted interest to repurpose this class of drugs. To identify the genetic determinants of innate β-lactam resistance, we carried out a synthetic lethality screen on a transpos...
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Methods We retrospectively included all ICU episodes in Ghent University Hospital during 2013 and 2014 with prescription of meropenem, piperacillin-tazobactam or ceftazidime for at least 48 hours, stratifying between ICU episodes of < and ≥4 days; for outcome analysis, only the first ≥4 days episode per patient was included. Deescalation was defined as a change from meropenem to a non-carbapene...
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The role of Aeromonas spp. in a variety of human illnesses has been well documented during the last decades. The spectrum of infectious diseases caused by Aeromonas species includes gastrointestinal and extraintestinal infections. Aeromonas gastrointestinal infections are generally self-limiting and antibiotic therapy is unnecessary. However, for gastrointestinal infections in immunocompromised...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2020
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.201911-2149le